INB/ELIXIR Spain launches tool to study the 3D structure of SARS-CoV-2 proteins

3DBionotes-Covid19 application logo

The ELIXIR Node in Spain has created a new COVID-19 tool for 3DBIONOTES-WS

Today, the Spanish National Centre for Biotechnology (CNB-CSIC), part of the INB/ELIXIR-ES, launches the 3DBIONOTES-COVID19 tool. The resource is integrated into 3DBIONOTES-WS, a web-based application for automatically annotating and visualising biomedical information ranging from immune epitopes sites to genomics data.

The new 3DBIONOTES-COVID19 tool will enable the study of antiviral targets and the visualisation and annotation of SARS-CoV-2 protein structures. The tool contains SARS-CoV-2 protein models from numerous sources: PDB-Redo, SwissProt, AlphaFold, European Projects and the repository of the Coronavirus Structural Taskforce.

A screenshot of a social media post

Description automatically generated

A screenshot from the 3DBionotes-Covid19application revealing the structure of SARS-CoV-2
spike receptor-binding domain complexed with its receptor ACE2 (left) and associated sequences (right).

The 3DBIONOTES Application Programming Interface (API) is an ELIXIR Recommended Interoperability Resource. This reusable platform-independent is key to gene metadata alignment, annotation, and integration across major bioinformatics data resources.

The Biocomputing Unit of the CNB-CSIC in Madrid hosts the 3DBIONOTES-COVID19 under the leadership of Prof José María Carazo and Dr Carlos Óscar Sánchez Sorzano, and in cooperation with INB/ELIXIR-ES and Instruct-ERIC (Instruct Image Processing Centre).